"50/50" is a balancing act of emotions, inspired by the true story of its writer.
Gordon-Levitt plays 27-year NRP radio reporter, Adam Lerner, who's life begins to unravel after discovering he has a rare and possibly fatal form of cancer.
Adam's friend, played by Seth Rogen, makes the tone of the movie upbeat despite the obvious tragedy.
As Adam copes with his new reality, he is also faced with an overbearing mother, pre-occupied girlfriend and inexperienced therapist.
Avoiding melodrama, "50/50" walks a uniquely balanced line between comedy and tragedy.
"50/50" opens September 30.
With Halloween a month away, "Dream House" offers preseason taste of horror.
Will Atenton, played by Daniel Craig, relocates his wife and two girls from New York to his dream house in a small New England town.
Unknown to the new owners, the home was the murder scene of a mother and her children, who many in the town believe were killed by the surviving husband.
As Will investigates, he'll discover a story that hits too close to home.
"Dream House" opens September 30.
Romantic comedy "What's Your Number?" also opens this weekend.
Ally Darling, played by Anna Faris, panics after reading an article predicting women who sleep with more than 20 men have no hope of settling down.
Ally begins sifting through her ex boyfriends, convinced she tossed her soul mate to curb.