Michael Dixon scored 21 points, including the game-winning layup with 31 seconds left, as No. 4 Missouri beat Texas 67-66 on Monday night.
Ricardo Ratliff and Phil Pressey added 13 points each for Missouri (20-2, 7-2 Big 12).
J'Covan Brown scored 20 for Texas (13-9, 3-6), which lost for the fifth time in six games, all to ranked teams. Two of those defeats were to Missouri.
Dixon's winning shot came seconds after J'Covan Brown had given Texas its first lead since the opening minutes.
Freshman Myck Kabongo had a chance to win it in the final seconds for the Longhorns, but he short-armed a baseline jumper and Missouri's Marcus Denmon grabbed the rebound.