Landry Jones passed for two touchdowns, Blake Bell ran for two more and No. 17 Oklahoma beat Texas Tech 41-20, avenging the Sooners' home loss to the Red Raiders last season.
The win was crucial for Oklahoma to remain in the conversation for the Big 12 title.
Both of Jones' touchdown passes went for 13 yards - one each to Justin Brown and Kenny Stills. Bell, in at quarterback, scored his touchdowns from a yard out.
Javon Harris put the game out of reach midway through the third quarter when he returned an interception 46 yards for a TD to put the Sooners (3-1, 1-1) up 38-13.
The Red Raiders had their worst defensive performance this year, giving up 380 total yards after coming in ranked No. 1 in the nation.
Seth Doege was 22 of 36 for 203 yards and had three interceptions for Texas Tech (4-1, 1-1).