Perry Jones III had 21 points and 12 rebounds, Pierre Jackson added 16 points and No. 6 Baylor bounced back after its first two losses of the season to beat Oklahoma 77-65 on Tuesday night.
The Bears (18-2, 5-2 Big 12) led throughout but needed a strong finish to put away the Sooners, who were within 62-60 in the final 5 minutes.
Quincy Acy contributed 13 points and three blocks for Baylor, which shot 54 percent to get back on the winning track after losses to Kansas and Missouri, both Top 10 teams.
Steven Pledger led Oklahoma (12-7, 2-5) with 17 points, and Romero Osby had 16 points and 11 rebounds.
It was only the second win in 18 tries for the Bears at the Lloyd Noble Center in a series that was heavily lopsided in the Sooners' favor until recent years.