Ryan Spangler had 15 points and a career-high 17 rebounds to help No. 23 Oklahoma defeat No. 8 Oklahoma State 88-76 on Monday night.
Jordan Woodard scored 18 points and reserve Tyler Neal added a season-high 15 points for the Sooners (17-4, 6-2 Big 12), who won their fourth straight game and claimed their third win over a ranked conference opponent this season.
Marcus Smart had 22 points, Phil Forte scored 20 points and made all six of his 3-point tries and Markel Brown added 18 points for the Cowboys (16-4, 4-3).
OSU's Le'Bryan Nash, who scored a career-high 29 points against West Virginia on Saturday, fouled out with eight points in 17 minutes.
It was the first time both teams have entered a "Bedlam" rivalry game ranked since 2005. The rematch is Feb. 15 at Oklahoma State.
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