TCU leading rusher Waymon James will miss the rest of the season for the 17th-ranked Horned Frogs because of a knee injury.
School spokesman Mark Cohen said Wednesday that the former Sherman Bearcat has a season-ending injury.
James, who appeared to get hurt in the fourth quarter of Saturday's win in Kansas, was averaging 9.9 yards on his 17 carries. He had 168 yards and a touchdown for TCU (2-0).
When asked Tuesday, coach Gary Patterson said James would be a game-time decision for Saturday's home game against Virginia. He didn't elaborate then.
With James and Matthew Tucker, TCU came into this season as one of only five FBS schools returning a pair of 700-yard rushers.
Tucker has 19 carries for 100 yards and a score, the 27th of his career.
James holds Sherman career records for rushing yards (4,732), total yards (5,305), rushing touchdowns (54) and total touchdowns (63).