Baker Mayfield completed 23 of 31 passes for 342 yards and three touchdowns and ran for a score to help No. 14 Oklahoma beat Iowa State 52-16 on Saturday night.
Samaje Perine ran for 95 yards and a touchdown on 13 rushes, and Joe Mixon rushed for 88 yards and a touchdown on eight carries for Oklahoma (8-1, 5-1 Big 12, No. 15 CFP). The Sooners have won fourth straight, outscoring their opponents 232-50.
Joel Lanning completed 26 of 51 passes for 260 yards and a touchdown for Iowa State (3-6, 2-4). The Cyclones have lost four of their last five.
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